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Synthesis and antimicrobial activity of 2-((4-(1H-benzo[d]imidazol-2-yl)-6-(2-ethylcyclopentyl) pyrimidin-2-yl)thio)-N-methylacetamide

By: Sunitha, Ch.
Contributor(s): Brahmeshwari, G.
Publisher: New Delhi CSIR 2022Edition: Vol.61(8), Aug.Description: 816-822p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here In: Indian journal of chemistry (Section B)Summary: It was possible to synthesise a brand new series of 2-((4-(1H-benzo[d]imidazol-2-yl)-6-(2-ethylcyclopentyl)pyrimidin-2-yl)thio)-N-methyl acetamide (4a-h). The reaction of 1-(1H-benzimidazol-2-yl)ethanone with 2-ethylcyclopentane carbaldehyde with ethanol and KOH yielded (E)-1-(1H-benzo[d]imidazol-2-yl)-3-(2-ethylcyclopentyl)prop-2-en-1-one (1a-c). All compounds shown to have antimicrobial action via pharmacological study are listed here. . Chloramphenicol and Amphotericin B, two conventional antibiotics, were compared to the antibacterial and antifungal properties of synthetic compounds. It was discovered that Schlenter products had spectroscopic properties worth investigating.
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It was possible to synthesise a brand new series of 2-((4-(1H-benzo[d]imidazol-2-yl)-6-(2-ethylcyclopentyl)pyrimidin-2-yl)thio)-N-methyl acetamide (4a-h). The reaction of 1-(1H-benzimidazol-2-yl)ethanone with 2-ethylcyclopentane carbaldehyde with ethanol and KOH yielded (E)-1-(1H-benzo[d]imidazol-2-yl)-3-(2-ethylcyclopentyl)prop-2-en-1-one (1a-c). All compounds shown to have antimicrobial action via pharmacological study are listed here. . Chloramphenicol and Amphotericin B, two conventional antibiotics, were compared to the antibacterial and antifungal properties of synthetic compounds. It was discovered that Schlenter products had spectroscopic properties worth investigating.

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